从纬度差异到分子机制：维生素D与糖尿病

From latitude differences to molecular mechanisms：vitamin D and diabetes

摘要:

维生素D作为人体必需的营养物质之一，近年来关于其调节钙磷代谢以外作用的研究不断涌现，并发现其与糖尿病这一病因复杂的慢性病之间有着千丝万缕的关系。本文通过描述近百年来人们的探索过程，从最初发现纬度差异与糖尿病发病率之间的关系入手，对维生素D与1型、2型、妊娠期糖尿病以及糖尿病并发症之间的关系进行阐述，并讨论了氧化应激、内质网应激等内源性信号通路在其对疾病的影响中可能的分子机制，以期为临床上更好地应用维生素D改善糖尿病患者病情提供思路。

Abstract:

Vitamin D，as one of the essential nutrients，becomes the hot spot of researches in recent years. Researches focusing on its function of regulating the metabolism of calcium phosphate have sprang up constantly，which have close relation diabetes，the complex chronic diseases. Therefore，we expounded on the relationship among vitamin D，and type 1，type 2，gestational diabetes，as well as di－abetes complications，and discussed on the possible molecular mechanism of endogenous signaling pathways like oxidative stress and endoplasmic reticulum stress in disease through describing the relationship between the latitude differences and the incidence of dia－betes，aiming to provide reference for clinical application of vitamin D in diabetes patients.