代谢组学分析在重症医学领域的研究与应用进展

Research and application progress of metabolomics analysis in critical care medicine

摘要:

重症医学领域的疾病常常以“综合征”为代表，即使是同样的一个结局，他们的病因也不尽相同。现行评估这些综合征的指标并不能完全反映机体所受到的压力。代谢组学是最新的“组学”技术，涉及生物体或特定生物样品小分子代谢物的全面分析。代谢组学提供了对细胞状态的洞察，并描述了生物体的实际健康状况。气相色谱-质谱法和液相色谱-质谱法等可用于各种生物流体的研究技术，用于重症监护室（intensive care unit，ICU）患者的代谢组学分析。这些技术已成功用于ICU和其他临床环境的诊断和预后，例如，脓毒症和急性呼吸窘迫综合征、急性肾损伤等。本文就代谢组学分析在重症医学领域的研究进展做一综述。

Abstract:

In the field of critical care medicine，the so-called ‘diseases’ are often ‘syndromes’. The same clinical outcome may have different etiologies. In fact，the current assessment of these syndromes does not reflect the whole changes of the patients’ body. Metabolomics is the latest ‘omics’ technique，which analyzes the small molecule metabolites of organisms or specific biological sam－ples comprehensively. And it provides an insight of actual（health or illness） condition of organisms from the cell status. Techniques for a variety of biological fluids，such as gas chromatography-mass spectrometry，liquid chromatograph-mass spectrometry have been used in ICU for the metabolic analysis. And they have been used in the diagnosis and prognosis of the syndromes or diseases，such as sepsis，acute respiratory distress syndrome，acute kidney injury and so on in the ICU. In this review，we will focus on the develop－ment of metabolomics analysis in critical care medicine.