3%高渗盐水与盐酸氨溴索雾化辅助治疗中-重度毛细支气管炎疗效比较

Comparison on efficacy of 3% hypertonic saline and ambroxol hydrochloride in the treatment of moderate to severe bronchiolitis in children

摘要:

目的：比较3%高渗盐水与盐酸氨溴索雾化治疗中-重度毛细支气管炎的疗效。方法：121例毛细支气管炎患儿入院后进行病情严重度评分，并按入院顺序分为2组，在常规治疗的基础上，1组予以3%高渗盐水雾化，1组予以盐酸氨溴索雾化。治疗3 d后，再次进行临床严重度评分并比较病情恢复情况以及住院天数差异。结果：2组患儿入院时病情严重度评分无统计学差异（P＞0.05），治疗3 d后，高渗盐水组与氨溴索组患儿较治疗前均有明显下降，差异有统计学意义（P<0.05），高渗盐水组中度（n=27，46.55%）与氨溴索组中度患儿（n=29，46.03%）（5.44±0.97 vs. 5.62±1.12）（P=0.533）差异无统计学意义，但高渗盐水组重度（n=31，53.45%）与氨溴索组重度患儿（n=34，53.97%）（7.39±1.43 vs. 8.26±1.33）（P=0.013）差异有统计学意义。高渗盐水组与氨溴索组患儿住院天数差异无统计学意义（P>0.05）。结论：3%高渗盐水与盐酸氨溴索雾化辅助治疗中-重度毛细支气管炎均有显著疗效，但对于重度毛细支气管炎，3%高渗盐水疗效更佳。

Abstract:

Objective：To compare the efficacy of 3% hypertonic saline and ambroxol hydrochloride in the treatment of moderate to se－vere bronchiolitis in children. Methods：The 121 children with bronchiolitis were graded when they were on admission according their state of an illness. They were divided into 2 groups randomly. Patients in one group were given aerosol inhalation with 3% hypertonic saline，while those in the other group were given aerosol inhalation with ambroxol hydrochloride，as well as the conventional treat－ment. Three days later，the two groups were all graded again according their state of an illness. Then the difference in efficacy and hospital stay were compared between the two groups. Results：There was no difference in the grades between the two groups when they were on admission（P >0.05）. Three days later，the grades of the two groups were significantly decreased than those before the treatment（P<0.05）. And there was no difference in grades between the moderate bronchiolitis of children（P=0.533）；the grades of severe bronchiolitis of children in the 3% hypertonic saline group were significantly decreased compared with those in the am－broxol hydrochloride group（P=0.013）. There was no difference in hospital stay between the two groups（P >0.05）. Conclusion：The therapies of 3% hypertonic saline and ambroxol hydrochloride are all effective for the moderate and severe bronchiolitis of children，but 3% hypertonic saline is more effective for severe bronchiolitis than ambroxol hydrochloride. There is no significant difference in the hospital stay between the 3% hypertonic saline group and ambroxol hydrochloride group for moderate and severe bronchiolitis of children.