心肌阳离子通道与心肌缺血再灌注损伤的研究进展

Research progress of myocardial cation channels and myocardial ischemia reperfusion injury

摘要:

心肌缺血再灌注损伤（myocardial ischemia-reperfusion injury，MIRI）是缺血心肌在恢复血流后常见的并发症。大量研究表明，分布于心肌细胞膜和相关细胞器的一些阳离子通道参与MIRI的相关病理生理过程：早期研究发现主要有Na+、K+和Ca2+ 离子通道参与MIRI过程，而近期最新发现瞬时受体电位（transient receptor potential，TRP）也参与MIRI过程，并可能成为新的MIRI药物干预靶点。本文拟对目前与MIRI密切相关的心肌细胞上Na+、K+和Ca2+及TRP等阳离子通道在MIRI病理生理中的作用作一综述。

Abstract:

Myocardial ischemia-reperfusion injury（MIRI） is a common complication of ischemic myocardium after restoring blood flow. A large number of studies have shown that some of the cationic channels distributed in the myocardial cell membrane and related organelles are involved in the related pathophysiological processes of MIRI. Early studies have found that Na+，K+ and Ca2+ channels are involved in the MIRI process. Recent studies find that transient receptor potential（TRP） is also involved in MIRI and may be the new interfering target of medicine treatment. This paper aims to review the roles of the myocardial cation channels such as Na+，K+，Ca2+ and TRP in MIRI.