基于内源性干细胞归巢的牙髓再生模式研究进展

Research progress in dental pulp regeneration strategy based on endogenous stem cell homing

摘要:

目前对于牙髓不可逆炎症和坏死患牙的标准治疗方法是根管治疗，但根管治疗不能恢复牙髓牙本质复合体的生理功能，不能形成修复性牙本质抵御外界侵袭。相比传统的根管治疗术，诱导根管内牙髓再生能达到更好的预后，也是今后的研究方向。研究表明利用组织工程原理将干细胞，合适的支架材料及信号因子植入到根管内可以形成牙髓样结构和管状牙本质。相比外源性干细胞移植的技术敏感性及潜在的安全性问题，基于内源性干细胞归巢实现牙髓再生的模式更加符合临床要求。现将基于内源性干细胞归巢实现牙髓再生模式的各个重要环节的研究进展综述如下。

Abstract:

By now，the standard treatment method for teeth with irreversible dental pulp inflammation and necrosis is root canal therapy. However，it cannot restore the physiological function of dental pulp dentin complex and form the reparative dentin to resist external invasion. Compared with traditional root canal surgery，inducing dental pulp regeneration in the root canal has a better prognosis and is the future research direction. It has been showed that dental pulp structure and tubular dentin can be formed by implanting stem cells，suitable scaffold materials，and signal factors into the root canal based on tissue engineering principle. Compared with the exogenous stem cell transplantation with technical sensitivity and potential safety problems，the dental pulp regeneration strategy based on endogenous cell homing can meet the clinical requirements. Current status and research progress in dental pulp regeneration strategy based on endogenous stem cell homing are summarized as follows.