先天性单纯性腋毛缺失与桥本甲状腺炎的相关性分析

An analysis of association between congenital simple absence of axillary hair and Hashimoto’s thyroiditis

摘要:

目的：探讨先天性单纯性腋毛缺失与桥本甲状腺炎（Hashimoto’s thyroiditis，HT）之间的关系。方法：选取116例甲状腺疾病患者，根据是否伴有先天性单纯性腋毛缺失分为2组，其中伴有先天性腋毛缺失的A组52例，男5人，女47人，平均年龄（35.3±11.5）岁，其中HT 46例，Graves病（GD）2例，甲状腺癌（thyroid carcinoma，TC）4例；对照（B）组64例，男26人，女38人，平均年龄（41.4±12.6）岁，其中GD 25例，HT 2例，TC 19例，结节性甲状腺肿（nodular goiter，NG）13例，亚急性甲状腺炎（suba－cute thyroiditis，ST）5例，对所有患者均进行性毛和甲状腺查体、甲状腺功能和甲状腺自身抗体检测以及甲状腺超声检查。结果：A组伴发HT的概率高达98.06%，而对照组仅为3.13%（P=0.000），且A组55.77%的患者有先天性单纯性腋毛缺失家族史（P=0.000），44.23%的患者有甲状腺疾病家族史（P=0.029），26.54%的患者目前为甲状腺功能减退（P=0.000），94.21%的患者TPOAb和TGAb阳性（均P=0.000）。结论：先天性单纯性腋毛缺失可能作为HT的遗传标志，为早期识别HT患者并及时干预提供临床依据。

Abstract:

Objective：To investigate the association between congenital simple absence of axillary hair and Hashimoto’s thyroiditis （HT）. Methods：A total of 116 patients with thyroid diseases were divided into two groups according to the presence or absence of congenital simple absence of axillary hair：52 patients with congenital simple absence of axillary hair as group A and 64 patients without congenital simple absence of axillary hair as group B. In group A，there were 5 male patients and 47 female patients；the mean age was 35.3±11.5 years；there were 46 HT patients，2 Graves’ disease（GD） patients，and 4 thyroid carcinoma（TC） patients. In group B，there were 26 male patients and 38 female patients；the mean age was 41.4±12.6 years；there were 25 GD patients，2 HT patients，19 TC patients，13 nodular goiter patients，and 5 subacute thyroiditis patients. All patients underwent physical examination for sex hair and the thyroid，thyroid function test，measurement of thyroid autoimmune antibodies，and thyroid ultrasound. Results：The proportion of HT patients in group A was significantly higher than that in group B（98.06% vs. 3.13%，P=0.000）. Among all patients in group A，55.77% had a family history of congenital simple absence of axillary hair，44.23% had a family history of thyroid diseases，26.54% had hypothyroidism，and 94.21% were positive for thyroid peroxidase antibody thyroglobulin antibody，and these proportions were significantly higher than those in group B（P=0.000，0.029，0.000，0.000，and 0.000）. Conclusion：Congenital simple absence of axillary hair may be a genetic marker of HT，thus providing clinical evidence for early identification of HT patients and timely inter－vention.