2型糖尿病患者血清Asprosin水平及其与代谢指标的 相关性研究

Relationship between serum asprosin level and metabolic indices in patients with type 2 diabetes mellitus

摘要:

目的：研究2型糖尿病患者血清Asprosin水平变化及其与代谢指标的相关性。方法：收集初诊2型糖尿病患者（type 2 diabetes mellitus，T2DM）98例和正常糖耐量人群（normal glucose tolerance，NGT）93例。进一步根据中国超重/肥胖医学营养治疗专家共识（2016年版），以体质量指数（body mass index，BMI）≥28 kg/m2为切点，将上述2组组内分别再分为非肥胖（non-obe－sity，NOB）和肥胖（obesity，OB）两亚组。测量人体指标、检测相关代谢血生化指标，采用ELISA检测血清Asprosin水平，并通过直线相关性分析、多元线性回归分析对Asprosin水平及其与其他代谢指标的相关性进行统计分析。结果：T2DM组Asprosin水平明显高于NGT组[（352.579±40.742） pg/mL vs. （189.411±32.635） pg/mL，P=0.002]。单因素相关分析显示，T2DM患者血清Asprosin水平与高密度脂蛋白胆固醇（high density lipoprotein-cholesterol，HDL-C）呈负相关（r=-0.447，P=0.000），与空腹血糖（fasting blood glucose，FBG）、空腹胰岛素（fasting insulin，FINS）、胰岛素抵抗指数（homeostasis model of assessment for insulin resistance index，HOMA-IR）、糖化血红蛋白（glycosylated hemoglobin，HbA1c）呈正相关（r=0.187，r=0.198，r=0.202，r=0.159，均P<0.05）。多元逐步回归分析发现，FBG（β=0.333，P=0.000）、HOMA-IR（β=-0.176，P=0.047）为血清Asprosin的独立影响因素。结论：T2DM组血清Asprosin水平明显高于NGT组，且与FBG、FINS、HOMA-IR、HbA1c呈正相关，与HDL-C呈负相关，其中FBG与HOMA-IR是血清Asprosin水平的独立危险因素。

Abstract:

Objective：To study the relationship between serum asprosin level and metabolic indices in patients with type 2 diabetes mellitus（T2DM）. Methods：A total of 98 patients with a preliminary diagnosis of T2DM and 93 subjects with normal glucose tolerance （NGT） were enrolled. According to the China Expert Consensus on Nutritional Therapy for Overweight or Obese Patients（2016），the two groups were further divided into non-obesity（NOB） and obesity（OB） subgroups，with body mass index（BMI）≥28 kg/m2 as the cut-off point. Body indices and metabolism-related blood biochemical indices were tested，and serum asprosin level was measured with ELISA. The correlation between asprosin level and other metabolic indices was analyzed by linear correlation and multiple linear regression. Results：The asprosin level in the T2DM group was significantly higher than that in the NGT group[（352.579±40.742） pg/mL vs. （189.411±32.635） pg/mL，P=0.002]. Univari－ate correlation analysis showed that the serum asprosin level of T2DM patients was negatively correlated with high-density lipoprotein-cholesterol（HDL-C）（r=-0.447，P=0.000），and positively correlated with fasting blood glucose（FBG），fasting insulin（FINS），homeostasis model of assessment for insulin resis－tance index（HOMA-IR），and glycosylated hemoglobin（HbA1c）（r=0.187，0.198，0.202，and 0.159，respectively，all P <0.05）. Stepwise multiple regression analysis showed that FBG （β=0.333，P =0.000） and HOMA-IR （β=-0.176，P=0.047） were independent risk factors for serum asprosin level. Conclusion：The serum asprosin level in T2DM patients is significantly higher than that in NGT patients；it is positively correlated with FBG，FINS，HOMA-IR，and HbA1c，and negatively correlated with HDL-C. FBG and HOMA-IR are independent risk factors for serum asprosin level.