颈内动脉弯曲与颅内动脉瘤发生的相关性研究

Relationship between internal carotid artery curvature and intracranial aneurysm in oxidative stress induced by H2O2

摘要:

目的：观察颈内动脉弯曲在颅内动脉瘤患者中的发生情况，探讨其与颅内动脉瘤发生是否存在相关性。方法：应用病例对照研究方法，回顾性分析177例动脉瘤患者（包括破裂动脉瘤患者及未破裂动脉瘤患者）及164例非动脉瘤患者（对照组）的一般病例资料，并通过颈部CT血管造影（computed tomogrphy angiography，CTA）影像资料将每例患者颈内动脉弯曲程度分为迂曲（tortuosity）、折曲（kinking）、襻曲（coiling）。先对动脉瘤组与对照组间颈内动脉弯曲程度及一般资料进行单因素分析，再将单因素分析中具有统计学意义的因素纳入多因素logistic回归分析，最后对颅内动脉瘤相关特征与颈内动脉弯曲程度的相关性进行分析。结果：折曲在动脉瘤组及对照组中分别为47例（26.6%）及26例（15.9%），单因素分析显示折曲与颅内动脉瘤发生显著相关（P=0.016），多因素回归分析结果显示折曲是影响颅内动脉瘤发生的独立因素（P=0.002，OR=2.573，95%CI=1.426~4.641）。在颅内动脉瘤相关特征与颈内动脉弯曲相关性分析中，颈内动脉弯曲与颅内动脉瘤是否破裂、大小及个数无相关性。结论：颈内动脉折曲改变是颅内动脉瘤发生的影响因素之一。

Abstract:

Objective：To observe the occurrence of internal carotid artery curvature in patients with intracranial aneurysm，and to in－vestigate whether there is correlation between internal carotid artery curvature and intracranial aneurysm. Methods：The general case data of 177 patients with aneurysms（patients with ruptured aneurysms and unruptured aneurysms） and 164 patients without a－neurysms（control patients） were retrospectively analyzed by case-control study. The internal carotid artery curvature was divided into no，tortuosity，kinking and coiling by computed tomogrphy angiography（CTA） images. Univariate analysis was performed on the degree of carotid artery tortuosity and general data between the aneurysm group and the control group，and then the multivariate logistic regression analysis was used to analyze the statistical significance factors of univariate analysis. Finally，the correlation between aneurysm-related features and internal carotid artery curvature was analyzed. Results：Kinking was 47 cases（26.6%） and 26 cases （15.9%） in the aneurysm group and in the control group. Univariate analysis showed that kinking was significantly correlated with the incidence of intracranial aneurysms（P=0.016）. Multivariate logistic regression analysis showed that kinking was an independent factor affecting the occurrence of intracranial aneurysms（P=0.002，OR=2.573，95%CI=1.426 to 4.641）. There was no correlation between internal carotid artery curvature and intracranial aneurysm rupture，size and number. Conclusion：Internal carotid artery curvature is one of the factors affecting the occurrence of intracranial aneurysm.