重庆市2 805例健康女性DXA法骨密度现况分析

An analysis of DXA-measured bone mineral density in 2 805 healthy women in Chongqing，China

摘要:

目的：通过测量重庆市2 805人次健康女性骨密度，初步建立重庆地区各年龄段骨密度数据库及骨峰值，并探讨年龄、体质量指数对骨密度变化的影响。方法：选取2011年6月至2015年11月在重庆市妇幼保健院体检的健康女性，采用双能X线骨密度仪测量腰椎1~4和股骨颈骨密度。结果：2 805例健康女性骨质疏松症发生率为11.44%；随着年龄增长，骨质疏松症比例增加（趋势卡方检验： χ2=403.800，P=0.000）；50岁以上骨质疏松症发生率为26.04%，50岁前后的正常骨量和骨质疏松症比例均有统计学差异（P=0.000）；35~39岁达到腰椎1~4骨密度峰值（1.116±0.120） g/cm2，17~19岁达到股骨颈骨密度峰值（0.935±0.146） g/cm2。结论：本研究建立了重庆市经DXA法测量腰椎及股骨颈骨密度的大数据。

Abstract:

Objective：To establish a preliminary bone mineral density（BMD） database and the peak BMD of people from different age groups in Chongqing，China，through the measurement of BMD in 2 805 healthy women in Chongqing，and to investigate the effect of age and body mass index on BMD. Methods：Dual-energy X-ray absorptiometry（DXA） was used to determine the BMD of the lumbar vertebrae（L1-4） and the femoral neck of healthy women who had physical examinations in Chongqing Health Center for Women and Children from June 2011 to November 2015. Results：The prevalence rate of osteoporosis in 2 805 healthy women was 11.44%，and it increased with age（ χ2=403.800，P=0.000）. The prevalence rate of osteoporosis in women over 50 years of age was 26.04%；there were significant differences in the proportions of women with normal bone mass and osteoporosis before and after the age of 50 years（P=0.000）. The peak BMD（1.116±0.120） g/cm2 of lumbar vertebrae was reached at the age of 35 to 39 years，and the peak BMD（0.935±0.146） g/cm2 of femoral neck was reached at the age of 17 to 19 years. Conclusion：In this study，a DXA-measured BMD database of lumbar vertebrae and femoral neck of people in Chongqing was established.