老年期抑郁的异质性与诊疗方案

The heterogeneity of senile depression and its diagnostic and therapeutic protocols

摘要:

老年期抑郁指年龄大于65岁后发生的抑郁，包括老年期首次起病的抑郁，也有年轻时发病持续到复发性抑郁。抑郁则不仅包括抑郁症（major depressive disorder，MDD），还包括各种类型的抑郁。老年期抑郁不少合并有脑退行病变或者脑血管性损害等器质性基础，也受到躯体疾病、环境因素、既往抑郁发作等其他因素的影响。本文将讨论老年期抑郁的异质性特点，区分各种老年期抑郁与相应的诊疗方案，为临床研究与诊治提供参考。

Abstract:

Senile depression refers to depression that occurs after the age of 65, including the first depression occurring in old age and recurrent depression from earlier age of onset. Depression includes not only major depressive disorder, but also various types of depression. Many cases of senile depression are comorbid with organic diseases such as degenerative brain diseases and cerebrovascular impairment, and are affected by other factors including physical disease, environmental factors, and previous depressive episodes. Here, the heterogeneity of senile depression will be discussed to distinguish between different types of senile depression, suggest the corresponding diagnostic and therapeutic protocols, and provide references for clinical research, diagnosis, and treatment.