肌萎缩侧索硬化分子生物学研究进展

Molecular biology advances in amyotrophic lateral sclerosis

摘要:

肌萎缩侧索硬化（amyotrophic lateral sclerosis，ALS）的发病机制目前尚不明朗，多种遗传因素促使ALS中运动神经元变性，增加疾病的易感性。随着近年来分子生物学技术的快速发展，ALS机制研究领域的主题也趋于多样化。因此，本文结合当前分子生物学领域最新成果和自身观点来阐述ALS可能的发病机制。

Abstract:

The pathogenesis of amyotrophic lateral sclerosis (ALS) remains unclear. Multiple genetic factors contribute to the degeneration of motor neurons and thus increase the susceptibility to ALS. With the rapid development of molecular biology techniques in recent years, there is an increasing diversity of research topics on ALS pathogenesis. Therefore, this article will illustrate the possible pathogenesis of ALS with reference to the latest achievements in the field of molecular biology and our own perspectives.