亚临床维生素A缺乏与重庆市及周边地区儿童生长痛的关系研究

Correlation analysis of marginal vitamin A deficiency and growing pains in children from Chongqing and surrounding areas

摘要:

目的：探讨亚临床维生素A缺乏与重庆市及周边地区儿童生长痛的关系，为生长痛儿童临床治疗提供依据。方法：对我院2015年11月至2017年9月临床上已排除其他疾病，诊断为生长痛且症状持续6个月以上的111名患儿，采用高效液相色谱法测定静脉血维生素A含量。其中男性患儿53例，女性58例；年龄：2.4～12.3岁，平均 5.8岁。采用同样的方法检测了176例同期来我院健康体检儿童的维生素A含量，其中男100例，女76例；年龄2.1～13.1岁，平均4.8岁。结果：生长痛组111名中有70例（63.1%）为维生素A亚临床缺乏；体检组维生素A亚临床缺乏有87例（49.4%），比较2组数据差异有统计学意义（χ2=5.104，P＜0.05）。结论：亚临床维生素A缺乏与重庆市及周边地区儿童生长痛存在相关性。

Abstract:

Objective：To investigate the correlation of growing pains and marginal vitamin A deficiency in children from Chongqing and surrounding areas，and provide evidence for the clinical treatment of growing pains. Methods：From December 2015 to September 2017，111 children with growing pains in our hospital were chosen as observation group，including 53 boys and 58 girls with an aver－age age of 5.8 years old. And 176 checkup children at the same period were selected as control group，including 100 boys and 76 girls with an average age of 4.8 years old. The serum level of vitamin A was measured by high performance liquid chromatography，and was compared between the two groups. Results：There were 70 children of marginal vitamin A deficiency in the observation group，and 87 in the control group. The rate of marginal vitamin A deficiency was significantly different between the two groups（70/111 vs. 87/176，chi-square test， χ2=5.104，P<0.05）. Conclusion：Marginal vitamin A deficiency may be associated with growing pains in children from Chongqing and surrounding areas.