Objective：To investigate the influence of season on blood parameters based on the data of healthy individuals undergoing physical examination. Methods：The research data were randomly selected from the physical examination database of healthy individ－uals at the Health Management Center & Physical Examination Center of Sichuan Provincial People’s Hospital. A nonparametric rank sum test was used to compare related indices across seasons. Results：Alanine aminotransferase（ALT） reached the peak in winter. Glu－cose（Glu），total cholesterol（TC），high-density lipoprotein cholesterol（HDL-C），red blood cell count（RBC），hematocrit（HCT），and hemoglobin（HGB） were lower in summer and higher in winter. Uric acid（UA），triglyceride（TG），direct bilirubin（DBil），total biliru－bin（TBil），and creatinine（CRE） reached the highest values in summer and the lowest values in winter. Conclusion：Seasonal varia－tion has influence on ALT，Glu，TC，HDL-C，RBC，HCT，HGB，UA，TG，DBil，TBil，and CRE. The results of this analysis provides a basis for the diagnosis，treatment，and monitoring of diseases in different seasons.
