High-pressure injection of iodine contrast media(ICM) through vascular access is a necessary step in contrast-enhanced CT,but it is hard for patients with severe and acute diseases or especially-bad vascular conditions to reach peripheral vascular ac-cess. Therefore,central venous catheter can be an alternative. This paper reviewed studies at home and abroad concerning the safety of high-pressure injection of ICM via central venous catheter,providing a reference to infusion channels for patients with particularly difficult puncture and a guidance for further research.