Objective:To investigate the effects of different scanning methods and medication with different computed tomography (CT) devices on subjects and their nursing care during coronary angiography. Methods:Based on the coronary computed tomography angiography(CCTA) guidebooks,subjects were divided into the group A and group B. Group A had scanning scheme a of the comput-ed tomography angiography(CTA) using the 2016 Siemens second-generation dual-source CT device in our hospital and medication in accordance with nurses’ experience;group B had scanning scheme b of coronary CTA using 2017 General Electrical(GE) wide detec-tor CT device in our hospital and medication based on iodine flow rate. The one-time examination success rate,contrast agent ex-travasation,adverse reaction rate,and the satisfaction of the subjects were observed. The difference was considered statistically signifi-cant if P<0.05. Results:Requirements for subjects’ cooperation,subjects’ individual factors,failure rate,rescanning rate and the inci-dence of contrast agent extravasation in the group B were lower than those in the group A;satisfaction degree in the group B was higher than that in the group A;all differences had statistical significance(P<0.05). However,the incidence of adverse reactions in two groups had no statistically significant difference(P>0.05). Conclusion:GE wide detector device combined with the iodine flow rate has low requirement for subjects’ cooperation and high one-time success rate,which can effectively improve the patients’ satisfaction degree and simplify the nursing process, worthy of promotion and application in clinical medical laboratory.