幽门螺杆菌感染与胃肠道微生态研究进展

Research advances in Helicobacter pylori infection and gastrointestinal microecology

摘要:

胃肠道微生态稳态在维持正常的宿主生理活动中发挥着重要作用，幽门螺杆菌（Helicobacter pylori，Hp）是常见的胃内病原菌，感染后可引起胃黏膜损伤，甚至导致胃癌发生。Hp在胃内定植可影响胃肠道微生态稳态，胃肠道菌群也可参与Hp致病过程，影响Hp致病结局。本文就Hp感染与胃肠道微生态之间的相互作用及其对Hp致病的影响进行综述。进一步揭示Hp感染对胃肠道微生态的影响，胃肠微生态在Hp感染致病中的作用及益生菌对Hp根除治疗的意义。

Abstract:

The homeostasis of gastrointestinal microecology plays a critical role in maintaining normal host physiological activity. He－licobacter pylori（Hp） is a common pathogenic bacterium in the stomach and can cause gastric mucosal injury and even gastric cancer after infection. Hp colonization in the stomach can affect the homeostasis of gastrointestinal microecology，and gastrointestinal micro－biota may be involved in the pathogenic process of Hp and thus affect the outcome of Hp infection. This article reviews the interaction between Hp infection and gastrointestinal microbiota and its influence on the pathogenesis of Hp，and reveals the influence of Hp in－fection on gastrointestinal microecology，the role of gastrointestinal microecology in the pathogenesis of Hp infection，and the signifi－cance of probiotics in Hp eradication.