丰富环境对吗啡成瘾干预的研究进展

Research advances in the interventional effect of environmental enrichment on morphine addiction

摘要:

丰富环境对神经可塑性有重要影响，丰富环境刺激可引起神经系统形态结构及行为功能的改变，作用机制涉及遗传、表观遗传和神经生物学等层面的变化；丰富环境能缓解甚至逆转吗啡暴露后的神经损害，对相关行为认知障碍的治疗，以及成瘾、复发的预防都有着潜在的指导意义。本文就丰富环境对吗啡成瘾干预的应用作一个简单的展望。

Abstract:

Environmental enrichment has a great influence on neural plasticity，and such stimulation can induce changes in the mor－phological structure and behavioral functions of the nervous system. The mechanism involves changes in genetics，epigenetics，and neurobiology. Environmental enrichment can alleviate or even reverse neurological damage after morphine exposure and has a potential guiding significance in the treatment of behavioral disorder and cognitive impairment and the prevention of addiction and recurrence. This article introduces the perspectives of environmental enrichment in the intervention of morphine addiction.