复发性抑郁障碍患者尿酸水平及其相关因素分析

An analysis of serum uric acid and its effect in patients with recurrent depressive disorder

摘要:

目的：探讨复发性抑郁障碍患者外周血清尿酸水平，及与临床特征的相关性。方法：对128例复发性抑郁障碍患者（复发抑郁障碍组）、120例首发抑郁障碍患者（首发抑郁障碍组）和252例健康对照者（正常对照组）行血清尿酸检测，同时采用9条目患者健康问卷（patient health questionnaire-9，PHQ-9）、广泛性焦虑障碍量表（generalized anxiety disorder-7，GAD-7）评定复发抑郁障碍组和首发抑郁障碍组抑郁焦虑症状的严重程度。结果：①多重线性回归分析提示，复发抑郁障碍组（β=-0.327，P<0.001）和首发抑郁障碍组（β=-0.154，P<0.001）血清尿酸水平低于正常对照组，复发抑郁障碍组（β=-0.169，P<0.001）血清尿酸水平低于首发抑郁障碍组，差异均有统计学意义。②复发抑郁障碍组血清尿酸水平与本次发作时间呈负相关（r=-0.242，P<0.001）。结论：抗氧化性能的下降可能与抑郁障碍有关，复发性抑郁障碍患者的抗氧化水平显著降低，且与本次发作时间相关。

Abstract:

Objective：To investigate serum uric acid in peripheral blood and its association with clinical features in patients with re－current depressive disorder. Methods：Serum uric acid was measured in 128 patients with recurrent depressive disorder（recurrent depressive disorder group），120 patients with first-episode depressive disorder（first-episode depressive disorder group），and 252 healthy controls（control group）. Patient health questionnaire-9（PHQ-9） and generalized anxiety disorder-7（GAD-7） were applied to assess the severity of depression and anxiety in the two diseased groups. Results：①Multiple linear regression analysis was performed and the results showed that the recurrent depressive disorder group and first-episode depressive disorder group had significantly lower serum uric acid levels than the control group（β=-0.327，P<0.001；β=-0.154，P<0.001），and the recurrent depressive disorder group had a significantly lower serum uric acid level than the first-episode depressive disorder group（β=-0.169，P<0.001）. ②The serum uric acid level in the recurrent depressive disorder group was negatively correlated with the duration of episode（r=-0.242，P<0.001）. Conclusion：Reduced antioxidative capacity might be associated with depressive disorder. Patients with recurrent depressive disorder have significantly reduced levels of antioxidant，which is also associated with the duration of episode.