间充质干细胞外泌体在糖尿病肾病治疗中的研究进展

Researchadvancesintheroleofmesenchymalstemcellexosomesintreatmentofdiabeticnephropathy

摘要:

糖尿病肾病（diabeticnephropathy，DN）已成为影响人类健康的重大问题，防治其发生发展备受业界关注。近年来，干细胞移植治疗策略在防治DN进展中已彰显潜力，尤其是间充质干细胞（mesenchymalstemcell，MSCs）移植治疗。越来越多的证据表明，MSCs主要以旁分泌方式发挥治疗功能，而其释放一系列纳米级囊泡（外泌体）则作为细胞间通讯的重要介质。MSCs可将干细胞表型传递给受体细胞，促进干细胞维持、分化、自我更新与修复，并且可能介导基质元件之间相互作用，促进受体细胞的组织修复再生。新近干细胞外泌体介导治疗慢性肾脏病已成为研究热点，在DN研究中已取得一定结果。本文主要就干细胞外泌体治疗DN的国内外研究最新进展进行综述并讨论。

Abstract:

Diabeticnephropathy（DN）hasbecomeamajorproblemaffectinghumanhealth，andthepreventionandtreatmentofitsdevelopmentandprogressionhasattractedmoreandmoreattentionintheindustry.Inrecentyears，stemcelltransplantationhasshowngreatpotentialinthepreventionandtreatmentofDN，especiallymesenchymalstemcells（MSCs）transplantation.MoreandmorestudieshaveshownthatMSCsmainlyexertatherapeuticeffectinaparacrinemode，andaseriesofnanoscalevesicles（exosomes）releasedbyMSCsactasanimportantmediatorforintercellularcommunication.Theseexosomescantransferstemcellphenotypetorecipientcells，promotestemcellmaintenance，differentiation，self-renewal，andrepair，mediateinteractionsbetweenmatrixelements，andpro－motetissuerepairandregenerationofrecipientcells.Stemcellexosome-mediatedtreatmentofchronickidneydiseasehasbecomearesearchhotspotinrecentyears，andsomeachievementshavebeenmadeinthetreatmentofDN.Thisarticlereviewstherecentad－vancesinstemcellexosomesinthetreatmentofDNinChinaandforeigncountries.