内皮祖细胞在防治糖尿病血管并发症的应用前景

Applicationprospectofendothelialprogenitorcellsonpreventionandtreatmentofdiabetes-relatedcardiovasculardiseases

摘要:

我国糖尿病的发病率和死亡率呈逐年上升趋势，继发于糖尿病的血管并发症已成为糖尿病患者死亡的主要原因。内皮祖细胞（endothelialprogenitorcells，EPCs）促进血管新生和修复血管损伤，EPCs耗竭和功能障碍导致糖尿病血管病变的发生发展。本文就EPCs对治疗糖尿病血管并发症的作用进行综述。EPCs是治疗糖尿病心血管病的一种新手段。EPCs移植治疗目前已经在动物实验水平证实有效，但仍缺乏大样本临床试验来验证EPCs移植治疗对糖尿病血管病变患者的有效性和安全性。适量饮酒、使用雌激素和他汀类药物、运动等，均可以刺激EPCs动员、增殖、迁移，并促血管新生，从而对治疗糖尿病心血管疾病具有重要意义。

Abstract:

TheincidenceandmortalityofdiabetesinChinaareincreasingyearbyyear，andvascularcomplicationssecondarytodiabeteshaveprovedtobethemaincauseofdeathindiabeticpatients.Endothelialprogenitorcells（EPCs）canpromoteangiogenesisandrepairimpairedvessels，whileEPCsdepletionanddysfunctionleadtothedevelopmentofdiabeticangiopathy.ThisarticlereviewstheroleofEPCsintreatmentandpreventionofdiabetes-relatedcardiovasculardiseases.EPCsprovideanewapproachtothetreat－mentofdiabetes-inducedcardiovasculardiseases.Althoughpositiveeffectsweredocumentedbyanimalstudybothinvivoandvitro，clinicaltrialswithlargesamplearestillrequiredtoverifytheefficiencyandsafetyofEPCstransplantationtherapyinpatientswithdiabetes-inducedcardiovasculardiseases.Moderatealcoholconsumption，useofestrogenandstains，aswellasphysicalexerciseetc.canstimulateEPCstomobilize，proliferateandmigrate，theycanalsopromoteangiogenesis，whichisofgreatsignificanceforthetreatmentofdiabetesinducedcardiovasculardiseases.