SDF-1促进糖尿病溃疡创面血管新生

SDF-1promotesdiabeticulcerwoundangiogenesis

摘要:

随着糖尿病发病率的逐年增长，糖尿病溃疡的关注度也在不断攀升。近年研究发现，基质细胞衍生因子-1（stromalcellderivedfactor-1，SDF-1）可以通过动员多种细胞因子促进血管新生，在糖尿病溃疡的愈合中发挥重要作用，其靶向治疗为糖尿病足等慢性溃疡治疗提供了新方向。本文主要就SDF-1与糖尿病溃疡创面血管新生的研究作一综述。

Abstract:

Asthenumberofpeoplewithdiabetesclimbs，theattentionondiabeticulcersisalsorising.Inrecentyears，thestudieshaveshownthatthestromalcellderivedfactor-1（SDF-1）axisinthemigrationoftransplantedangiogenesismobilizedbyvariedcy－tokineplaysanimportantroleinthehealingofdiabeticulcers，anditstargettreatmentprovidesanewwaytochroniculcerssuchasdiabeticfoot.ResearchesonSDF-1andangiogenesisindiabeticulcerwoundaremainlyreviewedinthisarticle.