婴幼儿血管瘤消退期的脂肪细胞形成

Formation of adipocytes in the involution phase of infantile hemangioma

摘要:

婴幼儿血管瘤是一种发生于婴儿的常见血管良性病变。多数婴幼儿血管瘤会在发病数年内自行消退，但是仍有部分患者无法自行消退，且引起一系列后遗症，因此对消退期的机制研究成为干预婴幼儿血管瘤正常消退的关键。脂肪细胞形成是婴幼儿血管瘤消退期的重要病理特征，而产生脂肪细胞的祖细胞一直是学术界争议的话题。本文结合最新的研究内容，讨论了大量出现在婴幼儿血管瘤消退期的脂肪细胞来源问题，阐述了其组织学和细胞学的观点，以及其中存在的内皮-间质转化机制，为婴幼儿血管瘤的临床干预提供思路。

Abstract:

Infantile hemangioma is a common benign vascular tumor of infancy. Involution often commences within several years after onset in most infants，but some patients still cannot achieve spontaneous regression. Infantile hemangioma may also cause a series of sequelae. Therefore，the research on the mechanism of involution is the key to normal involution of infantile hemangioma. The forma－tion of adipocytes is an important pathological feature of infantile hemangioma in the involution phase，and adipogenic progenitor cells have always been a controversial topic in the academic community. With reference to the latest research advances，this article discusses the source of the large number of adipocytes that appear in the involution phase of infantile hemangioma and elaborates on the histo－logical and cytological viewpoints and the role of endothelial-mesenchymal transition，in order to provide new thoughts for clinical in－tervention of infantile hemangioma.