围产期新型冠状病毒肺炎8例临床分析
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Clinical analysis of perinatal COVID-19 in eight pregnant women
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    摘要:

    目的:探讨围产期新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)患者的临床特点及母婴结局。方法:对华中科技大学同济医学院附属同济医院2020年1月19日至2月9日收治的8例围产期COVID-19确诊患者的临床资料进行回顾性分析,随访至2020年3月6日。分析包括患者的一般特征、临床特点和母婴结局。结果:①8例围产期COVID-19患者平均年龄(31.50±2.67)岁,经产妇6例,初产妇2例,孕晚期发病6例,产褥期发病2例。②8例患者均为轻型,症状表现为中低热(6/8),咳嗽、咳痰(4/8),胸闷、头晕、乏力、肌肉酸痛、呕吐(1/8);化验结果显示淋巴细胞百分比降低(6/8),淋巴细胞数目减少(3/8),肝酶升高(2/8);肺部CT阳性者7例。③分娩孕周为36+5~40+6周,其中7例行剖宫产,1例经阴道分娩,分娩新生儿共8例,均无新生儿窒息,1例新生儿出生36 h咽拭子核酸检测阳性。结论:围产期COVID-19患者绝大部分为轻型或普通型,且短期母婴结局良好,其他临床表现不典型,与非孕期相似。新型冠状病毒(2019 novel coronavirus,2019-nCoV)是否可以通过胎盘垂直传播及对后代产生近远期危害目前仍不明确,尚待进一步积累资料。

    Abstract:

    Objective:To explore and analyze the clinical characteristics and maternal-neonatal outcome of perinatal coronavirus dis-ease 2019(COVID-19). Methods:Clinical data of eight pregnant women who were confirmed with COVID-19 in our hospital from 19th January to 9th February,2020 were retrospectively analyzed. Outcomes were followed up until March 6,2020. General characteristics,clinical features,and maternal and neonatal outcomes were analyzed. Results:①The average age of eight patients was (31.50±2.67) years old,including six multiparas and two primiparas. Six patients experienced onset of illness in late pregnancy,while two in puer-perium. ②Eight patients were in mild situation,with moderate-low temperature(6/8),cough,expectoration(4/8),chest tightness,dizzi-ness,myalgia,and vomiting(1/8);decreased percentage of lymphocytes(6/8),decreased lymphocytes(3/8) and elevated aminotrans-ferase concentrations(2/8);positive lung CT(7/8). ③The range of gestational weeks of delivery was 36+5 to 40+6 weeks. Seven patients had a cesarean section and one had a vaginal delivery. Eight livebirths were recorded. No neonatal asphyxia was observed in newborns. The 36h nasopharyngeal swab in one newborn showed positive COVID-19. Conclusion:Most of patients with perinatal COVID-19 are mild or normal,and short-term maternal and neonatal outcomes are good. Other clinical manifestations are not typical,similar to the non-pregnant. It remains unclear whether COVID-19 can transmit vertically through placenta and consequently lead to short-term or long-term harm to neonates,and data need to be further accumulated.

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张慧婷,高绚,冯玲,杨凌艳,陈素华,林星光,乌剑利,郭立丽,陈玲,刘为勇,孙自镛,王少帅.围产期新型冠状病毒肺炎8例临床分析[J].重庆医科大学学报,2020,45(7):916-

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  • 在线发布日期: 2020-09-14
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