新型冠状病毒肺炎肝损伤特征分析

Characteristics of hepatic damage in patients with coronavirus disease 2019

摘要:

目的：分析新型冠状病毒肺炎（coronavirus disease 2019，COVID-19）患者肝功能损伤的特征。方法：回顾性分析2020年1月21日至2月20日重庆医科大学附属永川医院收治确诊的90例COVID-19患者临床资料，总结分析COVID-19发生肝功能损伤的原因及特征。结果：90例确诊患者共33例出现肝功能损伤，肝功能损伤率为36.7%，发生肝功能损伤的平均时间为（9.0±6.1） d；轻症组肝功能损伤率为32.5%，重症组肝功能损伤率为61.5%，差异具有统计学意义（P<0.05）；轻症组体质指数（body mass index，BMI）为（24.3±2.3） kg/m2，重症组BMI为（22.7±3.6） kg/m2，差异具有统计学意义（P<0.05）；肝功能损伤与性别、年龄、肝脏基础疾病无统计学差异（P>0.05）。结论：出现肝功能损伤以轻度损伤为主，与原发疾病、疾病严重程度、BMI有关，药物、肝脏基础疾病可能起了一定促进作用。随着原发病好转，肝损伤逐渐好转，预后较好。

Abstract:

Objective：To analyze the characteristics of hepatic damage in patients with coronavirus disease 2019（COVID-19）. Methods：Clinical data of 90 patients with COVID-19 from January 21，2020 to February 20，2020 were analyzed retrospectively. The causes and characteristics of hepatic damage in COVID-19 were analyzed and summarized. Results：Among 90 patients，33 had hepatic damage，with the rate of 36.7%. The average time of hepatic damage was 9.0±6.1 days. The rate of hepatic damage in the mild group was 32.5% and in the severe group was 61.5%，showing a statistical difference（P<0.05）. BMI in the mild group was （24.3±2.3） kg/m2 and in the severe group was （22.7±3.6） kg/m2，with significant difference（P<0.05）. There was no statistical difference between hepatic damage and gender，age and the underlying liver disease（P>0.05）. Conclusion：The hepatic damage in COVID-19 patients is mainly mild，which is related to the primary disease，the severity of the disease and BMI，The drug and the underlying liver disease may play a certain promoting role. With the improvement of the primary disease，the liver injury is gradually improved，with good prognosis.