肠道微生态与放射性肠炎发生发展的相关性

Correlation between gut micro-ecology and development of radiation enteritis

摘要:

稳定的肠道微生态是维持人体健康的重要保障和必要条件。肠道微生态的失衡和紊乱与多个系统疾病的发生发展有关，与肠道疾病的关系尤为密切。放射性肠炎是腹盆腔及腹膜后恶性肿瘤患者经放射治疗后并发的肠道放射性损伤，它的发生发展过程很复杂。肠道微生态失衡是形成该疾病的一个重要因素；而它的常规药物治疗效果非常有限，以调整肠道微生态为核心的治法表现出较好的治疗效果和安全性。本文从肠道微生态对放射性肠炎发生发展的影响机制进行综述，为临床通过调整肠道微生态治疗放射性肠炎提供依据。

Abstract:

Stable gut micro-ecology is an important guarantee and necessary condition for maintaining human health. The imbalance and disorder of gut micro-ecology are related to the occurrence and development of many diseases，and its relationship with intestinal diseases is particularly close. Radiation enteritis is a radiation injury of the intestines in patients with abdominal and retroperitoneal malignant tumors after radiotherapy. The process of is occurrence and development is complex，and gut micro-ecological imbalance is an important factor in the formation of the disease. Effect of conventional drug treatment effect is very limited for radiation enteritis，and therapies focusing on gut micro-ecology has shown better therapeutic effect and safety. Therefore，this paper reviews the mecha－nism of the influence of gut micro-ecology on the development of radiation-induced enteritis in hope of providing a basis for the clin－ical treatment of radiation enteritis via regulation of gut micro-ecology.