自噬在重症胰腺炎免疫抑制中的潜在作用及意义

Potential function and significance of autophagy on the immunosuppression of severe acute pancreatitis

摘要:

重症胰腺炎（sever acute pancreatitis，SAP）是常见的腹部急症之一，有病情重且病死率高、预后差的特点。免疫抑制在SAP病情发生发展过程中起推动作用。自噬作为一种细胞活动，不仅参与SAP期间胰蛋白酶原的活化，还对机体免疫系统具有明显影响。SAP不同阶段，免疫细胞和自噬均出现不同的状态，本文就自噬在SAP免疫抑制中的潜在作用及意义作一综述。

Abstract:

Severe acute pancreatitis（SAP） is one of the common abdominal emergencies，which is often characterized by severe con－dition，high mortality and poor prognosis. However，immunosuppression plays a promoting role in SAP progression. Autophagy，as a cel－lular activity，not only participates in the activation of trypsinogen during SAP，but also significantly influences the immune system. In different stages of SAP，immune cells and autophagy demonstrates different forms. This paper reviewed the potential function and sig－nificance of autophagy in SAP immunosuppression.