西藏昌都市藏汉族人群体液免疫指标水平调查

Investigation of the humoral immune index levels among Tibetans and Hans in Changdu，Tibet

摘要:

目的：对西藏昌都市藏汉族人群体液免疫指标水平进行调查，比较藏汉族人群之间以及其与重庆地区人群之间的差异，并探讨当地参考区间的建立。方法：收集2018年4月至9月西藏昌都市人民医院392例体检人群的血清标本，其中藏族195例、汉族197例，用免疫散射比浊法检测其血清免疫球蛋白IgA、IgG、IgM和补体C3、C4水平，并与重庆医科大学附属第一医院200例体检人群的体液免疫指标水平进行比较，分析不同地区、民族、性别之间的差异。结果：昌都地区C3（Z=-11.900，P=0.000）、IgM（Z=-3.063，P=0.002）水平高于重庆地区，而其IgA水平低于重庆地区（Z=-4.287，P=0.000），C4、IgG水平差异无统计学意义。昌都地区中藏族人群C3水平高于汉族人群（Z=-2.799，P=0.005），其余差异无统计学意义。藏族人群中女性IgG（t=-3.787，P=0.000）、IgM（Z=-6.736，P=0.000）水平明显高于男性，汉族人群中女性IgG（Z=-3.817，P=0.000）、IgM（Z=-3.356，P=0.001）水平也高于男性；藏族男性人群C3水平高于汉族男性人群（Z=-3.489，P=0.000），但IgM水平低于汉族男性人群（Z=-2.521，P=0.012），而藏族女性人群与汉族女性人群体液免疫指标水平差异无统计学意义。结论：西藏昌都市藏汉族人群体液免疫指标水平与重庆地区有一定的差别，且藏汉族之间及不同性别之间也存在差异，需根据当地不同健康人群建立适用的参考区间。

Abstract:

Objective：To investigate the levels of the humoral immune index among Tibetans and Hans in Changdu，Tibet，and com－pare the differences between the two groups，and that between samples in Tibet and Chongqing. Furthermore，to discuss the establish－ment of local reference intervals. Methods：Serum samples were collected from 392 subjects who underwent physical examination in The Changdu People’s Hospital of Tibet from April to September 2018，including 195 Tibetans and 197 Hans. Serum IgA，IgG，IgM，complement C3 and C4 levels were detected by immune scatter turbidity method，which were compared with the humoral immune index levels of 200 subjects who underwent physical examination in The First Affiliated Hospital of Chongqing Medical University，so as to analyze the differences among different regions，nationalities and genders. Results：The levels of complement C3（Z=-11.900，P=0.000） and IgM（Z=-3.063，P=0.002） in Tibet were higher than those in Chongqing while the level of IgA was lower than that in Chongqing（Z=-4.287，P=0.000） and there were not significant differences in the levels of complement C3 and IgG. In Tibet，the C3 level of the Tibetans was higher than that of the Hans（Z=-2.799，P=0.005），and the rest showed no significant difference. The levels of IgG（t=-3.787，P=0.000） and IgM（Z=-6.736，P=0.000） in female Tibetans were significantly higher than those in the males，and the levels of IgG（Z=-3.817，P=0.000） and IgM（Z=-3.356，P=0.001） in female Hans were also higher than those in male Hans. Addi－tionally，the C3 level in male Tibetans was higher than that in male Hans（Z=-3.489，P=0.000） while the IgM level in male Tibetans was lower than that in male Hans（Z=-2.521，P=0.012）. However，there were no significant differences between Tibetan female popu－lation and Han female population in humoral immune index levels. Conclusion：The humoral immune index levels of Tibetan and Han people in Changdu，Tibet are different from those in Chongqing，and differences between different nationalities and genders are also present. Therefore，specific reference intervals should be established according to the healthy population of each group.