针灸治疗阿尔茨海默病的分子生物学研究进展

Advances in molecular biology of acupuncture on treating alzheimer’s disease

摘要:

随着人口老龄化的加剧，阿尔茨海默病（Alzheimer’s disease，AD）作为一种不可逆的神经系统退行性疾病困扰着各国人民，给家庭及社会均带来了沉重的负担。针灸以其安全、简便、效果良好的优势在AD的临床治疗中发挥越来越重要的作用。该文归纳了近5年针灸治疗AD的分子生物学研究，总结了针灸通过调节异常蛋白的水平、调节中枢胆碱能系统、保护神经元、调节能量代谢、抑制炎性反应、上调自噬活性水平等途径达到治疗AD的作用，为临床应用针灸治疗AD提供理论基础。

Abstract:

With the aggravation of population aging，Alzheimer’s disease（AD），as an irreversible neurodegenerative disease，plagues people all over the world and brings a heavy burden to families and the society. Acupuncture plays an increasingly important role in the clinical treatment of AD with its advantages of safety，simplicity and good effect. This paper summarizes the molecular biology researches of acupuncture in the treatment of AD in the past five years and also concludes the treatment effects of acupuncture on AD achieved by regulating the level of abnormal proteins，regulating the central cholinergic system，protecting neurons，regulating energy metabolism，inhibiting inflammatory response，and increasing the level of autophagic activity. That provides a theoretical basis for the clinical application of acupuncture in the treatment of AD.