2型糖尿病患者默认网络和视觉网络的独立成分分析研究

Study on default mode network and visual network in patients with type 2 diabetes mellitus based on independent component analysis

摘要:

目的：采用独立成分分析（independent component analysis，ICA）探究2型糖尿病（type 2 diabetes mellitus，T2DM）患者默认网络（default mode network，DMN）和视觉网络（visual network，VIS）功能连接（functional connectivity，FC）变化情况。方法：选取T2DM伴视网膜病变患者（T2DM with retinopathy，R+组）25例和T2DM不伴视网膜病变患者（T2DM without retinopathy，R-组）22例组成T2DM组，健康对照（health controls，HCs）组29例，进行静息态功能磁共振扫描、数据预处理、ICA分析，选出DMN和VIS网络，比较组间脑网络的功能连接变化情况，分析差异脑区FC值与临床参数及认知评分的相关性。结果：与健康对照组相比，T2DM组DMN功能连接减弱脑区为左侧辅助运动区及左侧额上回，功能连接增强脑区为双侧内扣带回；T2DM组VIS功能连接减弱脑区包括右侧距状回、右侧楔叶及双侧舌回，无功能连接增强脑区。与R-组比较，R+组DMN无功能连接变化脑区；R+组VIS功能连接减弱脑区为左侧距状回、右侧枕中回和右侧顶下小叶，无功能连接增强脑区。T2DM组右侧舌回的FC值与体质指数（body mass index，BMI）呈负相关（r=-0.434，P=0.003）。结论：T2DM患者的DMN及VIS功能连接异常，提示部分脑网络受损，以R+组视觉网络受损更明显，为临床早期诊断T2DM认知功能障碍提供了可能的影像学途径。

Abstract:

Objective：To investigate the change of the functional connectivity（FC） of default mode network（DMN） and visual net－work（VIS） in type 2 diabetes mellitus（T2DM） patients by using independent component analysis（ICA）. Methods：T2DM patients with retinopathy（R+，n=25） and without（R-，n=22） retinopathy were recruited as the T2DM group and 29 healthy controls were en－rolled（HCs group）. Resting-state fMRI scanning，data preprocessing and ICA analysis were performed and DMN and VIS networks were selected. changes of FC between groups were compared and correlation between FC scores in different brain regions，and clinical parameters and cognitive scores was analyzed. Results：Compared with the HCs group，the FC of DMN in the T2DM group was signif－icantly decreased in the left supplementary motor area and the left superior frontal gyrus，while was increased in the bilateral medial cingulate cortex；the FC of VIS decreased in the right calcarine gyrus，the right cuneus cortex and bilateral lingual gyrus，but no FC of VIS was increased. Compared with the R- group，no significant differences about the FC of DMN in the R+ group；the FC of VIS was decreased in the left calcarine gyrus，the right middle occipital gyrus and the right inferior parietal lobule，but no FC of VIS was in－creased. FC scores of the right lingual gyrus were negatively correlated with the body mass index（BMI）（r=-0.434，P=0.003） in T2DM patients. Conclusion：The abnormal FC of DMN and VIS in T2DM patients suggests the impairment of some brain networks，especially the VIS in the R+ group，which may provide a possible imaging pathway for early diagnosis of cognitive dysfunction in T2DM.