PKCβ与糖尿病并发症的研究进展

Research progress of PKCβ and diabetic complications

摘要:

蛋白激酶Cβ（protein kinase Cβ，PKCβ）属于经典型PKC亚型，在高血糖诱导下发生活化并引起多种糖尿病并发症。活化的PKCβ通过下游信号通路引起内皮功能障碍、诱导白细胞黏附、调节细胞因子和转录因子表达，引起包括动脉粥样硬化、心肌病、脑卒中在内的大血管并发症和包括糖尿病肾病、视网膜病和周围神经病变在内的微血管并发症。本文对PKCβ在糖尿病并发症中的作用及其在临床治疗应用方面的相关研究作一阐述。

Abstract:

Protein kinase Cβ（PKCβ） is a classical PKC subtype，which can be induced and activated by hyperglycemia，leading to a variety of diabetes complications. Activated PKCβ causes endothelial dysfunction，induces white blood cell adhesion，regulates the ex－pression of cytokines and transcription factors through downstream signaling pathways，leading to macrovascular complications，such as atherosclerosis，cardiomyopathy and apoplexy and microvascular complications，such as diabetic nephropathy，retinopathy and pe－ripheral neuropathy. In this paper，the role of PKCβ in diabetic complications and its related research in clinical treatment were described.