自噬在糖尿病肾病发病机制中的研究进展

Research advances of autophagy in the pathogenesis of diabetic nephropathy

摘要:

糖尿病肾病是导致终末期肾脏疾病的主要病因之一。目前对该疾病最有效的治疗方案是使用肾素-血管紧张素系统抑制剂严格调控血糖和血压的保守治疗。然而，这只能控制糖尿病肾病的进一步恶化，仍会有部分患者继续发展至终末期肾病。因此，对于糖尿病肾病的治疗迫切需要找到新的治疗靶点。研究表明自噬是维持细胞内稳态的重要途径。其中失调的自噬可导致糖尿病患者肾脏的肾小球和肾小管间质病变，这可能是糖尿病肾病的发病机制之一。本文以自噬和糖尿病肾病相关的研究作一综述，以期总结现阶段自噬在糖尿病肾病发病机制中的研究进展，并展望自噬对糖尿病肾病治疗的意义。

Abstract:

Diabetic nephropathy is one of the main causes of end-stage renal disease. At present，the most effective treatment for this disease is conservative treatment with by using renin-angiotensin system inhibitors to strictly regulate blood glucose and blood pres－sure. However，this can only control the further deterioration of diabetic nephropathy，and some diseases will develop into the end-stage renal disease. Therefore，to find new therapeutic targets for treating the diabetic nephropathy is in urgent needs. Studies have shown that autophagy is an important way to maintain cell homeostasis. The deregulated autophagy can lead to glomerular and tubulointerstitial lesions of kidneys in diabetic patients，which may be one of the pathogenesis of diabetic nephropathy. This article reviewed researches of autophagy and diabetic nephropathy，in order to summarize the research advance of autophagy in the pathogen－esis of diabetic nephropathy and to investigate the significance of autophagy in the treatment of diabetic nephropathy.