Objective:To develop the risk prediction model of psychological distress in lung cancer patients by using structural equa-tion model. Methods:A total of 441 hospitalized patients with lung cancer were randomly selected and questionnaires or scales were used to investigate the general information,psychological distress,stigma,illness perception,social support,perceived stress,coping style,mindfulness and self-esteem. Structural equation model was used to analyze the association between those factors and psycho-logical distress. Results:The structural equation model for psychological distress in lung cancer patients had a good fitting degree and its results showed that social support had a direct negative effect(β=-0.540,P=0.001) and an indirect negative effect(β=-0.003) on psychological distress,perceived stress had a direct negative effect(β=0.181,P=0.001) and an indirect negative effect(β=0.004) on psychological distress,coping style had a direct positive effect(β=0.114,P=0.005),mindfulness(β=-0.021) and stigma(β=-0.201) had indirect negative effect on psychological distress,educational level had a direct(β=0.147,P=0.003) and an indirect positive effect(β=0.026) on psychological distress,family income had a direct negative effect(β=-0.105,P=0.027) and an indirect positive effect(β=0.108) on psychological distress,age had a direct negative effect(β=-0.101,P=0.019) on psychological distress,occupational status had a positive effect(β=0.094,P=0.032) on psychological distress,and drinking history(β=0.031) and cancer stage(β=0.031) had an indirect effect on psychological distress. Conclusion:The risk prediction model which was con-structed in the present study is acceptable for patients. Path analysis of all risk factors suggests that the psychological dis-tress of lung cancer patients is influenced by many different factors in different ways and he social support,coping style,mindfulness,stigma,age,family income,educational level,occupational status,drinking history and cancer stage are key predictors