Objective:To explore effectiveness of IIFAR(initial check,information exchange,final accuracy check,reaction) information care model on distress,anxiety and depression in lung cancer patients. Methods:Randomly 132 inpatients with lung cancer were enrolled and assigned to two groups. Patients in the intervention group received IIFAR information care model in addition to routine health education. And the control group received routine health education. The scores of distress thermometer(DT),hospital anxiety and depression Scale(HADS) and the causes of distress were compared between the two groups. Results:There was no significant difference between two groups before the intervention(P>0.05). The results of inter-group analysis showed that the scores of DT,anxiety subscale and depression subscale in intervention group(1.81±1.16,1.26±1.41,2.74±2.53) was lower than those in control group(2.70±1.57,3.12±2.16,5.72±4.08) after intervention(t=3.521,P=0.001;t=5.519,P=0.000;t=-4.779,P=0.000). The results of intra-group analysis showed that after intervention the scores of DT,anxiety subscale and depression subscale was lower than before in intervention group(3.33±1.67,3.82±2.19,6.21±4.01)(t=9.397,P=0.000;t=10.131,P=0.000;t=9.148,P=0.000),and no significant difference in control group(P>0.05). Compared with control group,worry,sleeping,fear,tension and financial problems were alleviated in intervention group(P<0.05). Conclusion:Information care can relieve distress,anxiety and depression in lung cancer patients.