皮质基底节变性的影像诊断研究进展

Advances in imaging diagnosis of corticobasal degeneration

摘要:

皮质基底节变性（corticobasal degeneration，CBD）是一种以不对称的运动症状和大脑皮质功能障碍为主要表现的神经退行性疾病。金标准为病理诊断，临床特征的异质性以及与其他神经退行性疾病在症状和病理方面的重叠性使得诊断难度大。现行诊断标准正确率较低，未将影像学纳入其中。本文主要综述近几十年CBD的影像学进展，包括计算机断层扫描（computed tomography，CT）、磁共振成像（magnetic resonance imaging，MRI）、放射性核素显像等，以及其在疾病鉴别方面的贡献。

Abstract:

Corticobasal degeneration (CBD) is a neurodegenerative disease characterized by asymmetric motor symptoms and cerebral cortical dysfunction, with pathological diagnosis as gold standard. Due to the heterogeneity of clinical features and the overlapping with other neurodegenerative diseases in symptoms and pathology, the diagnosis of CBD is difficult. The correct rate of current diagnostic criteria is low and the imaging is excluded. In this paper, we give a review of the progress in imaging of CBD in recent decades, including computed tomography (CT), magnetic resonance imaging (MRI), radionuclide imaging, and their contributions in identification of CBD with other diseases.