剑桥语义测验在语义性痴呆患者中的应用研究

Cambridge semantic memory test battery applied research among patients with semantic dementia

摘要:

目的： 检测剑桥语义测验（Cambridge semantic memory test battery，CST）在语义性痴呆（semantic dementia，SD）患者中的研究应用。 方法： 对26例SD患者、25例正常对照组受试者均进行语言量表及其他包括简易精神状态检查量表（mini-mental state examination，MMSE）和蒙特利尔认知评估（Montreal cognitive assessment，MoCA）在内的全面的神经心理学测评。 结果： ①SD组整体测评结果均差于正常对照组（P<0.001）；②CST的4个分项测验在检测SD患者与正常对照组时的AUC值分别为0.984（95%CI=0.951~1.000）、0.915（95%CI=0.826~1.000）、0.898（95%CI=0.808~0.988）、0.857（95%CI=0.733~0.980）（P<0.001）。③采用双变量分析CST结果与MMSE、MoCA及综合性认知评估、日常生活能力量表（activity of daily living scale，ADL）、临床痴呆评定量表（clinical dementia rating scale，CDR）等结果在0.01层面具有显著相关性（P<0.001）；④SD组患者核磁显示SD患者具有明显的颞叶前下部萎缩，且侧重于左侧，并与相关神经心理学量表测评结果相符。 结论： CST可用于筛查SD患者。

Abstract:

Objective: To detect the application of the Cambridge semantic memory test battery (CST) in patients with semantic dementia (SD). Methods: In the study, 26 SD patients and 25 normal control subjects were given language scales and other tests including mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA). Results: ①The overall evaluation results of the SD group were worse than those of the normal control group (P<0.001). ②The AUC values of the 4 subtests of CST in the detection of SD patients and the normal control group were 0.984 (95%CI=0.951-1.000), 0.915 (95%CI=0.826-1.000), 0.898 (95%CI=0.808-0.988), 0.857 (95%CI=0.733-0.980) (P<0.001). ③Bivariate analysis of CST results and MMSE, MoCA, comprehensive cognitive assessment, activity of daily living scale (ADL), clinical dementia rating scale (CDR) and other results had significant correlation at the 0.01 level (P<0.001). ④SD patients had significant atrophy of the anterior lower part of the temporal lobe, and focused on the left side, which was consistent with the evaluation results of the relevant neuropsychological scale. Conclusion: CST can be used to screen SD patients.