主观认知下降生化诊断标志物的研究进展

Research progress of biochemical diagnostic markers of subjective cognitive decline

摘要:

阿尔茨海默病（Alzheimer's disease，AD）是痴呆的主要病因之一，主观认知下降（subjective cognitive decline，SCD）被认为是AD的临床前期，早期诊断SCD对AD的防治具有重大意义。在SCD的各种诊断方法中，生化诊断手段是一种较为简单、成本低廉、创伤小的诊断方式。将生化诊断方法与神经心理评估方式相结合，在SCD的诊断中具有较好的前景。本文就SCD的脑脊液、血浆、尿液等生化检测方法的研究进行综述。

Abstract:

Alzheimer's disease (AD) is one of the main causes of dementia, and subjective cognitive decline (SCD) is considered as the pre-clinical stage of AD. Early diagnosis of SCD is of great significance to the prevention and treatment of AD. Among various diagnostic methods of SCD, biochemical diagnosis is one relatively simple, low cost and less invasive. The combination of biochemical diagnosis and neuropsychological assessment has a good prospect in the diagnosis of SCD. Therefore, this paper has reviewed the research on cerebrospinal fluid, plasma, urine and other biochemical detection methods of SCD.