语义性痴呆患者的定量脑电图分析

Quantitative electroencephalogram analysis in patients with semantic dementia

摘要:

目的： 探讨语义性痴呆（semantic dementia，SD）患者的脑电图量化分析特点。 方法： 选取SD患者9例和性别年龄匹配的正常人30例进行脑电图（electroencephalogram，EEG）检查。记录EEG检查结果，测量全脑、左额、右额、左前颞叶、右前颞叶、左中后颞、右中后颞、左中央、右中央、左顶、右顶、左枕、右枕区各频段（δ+θ）/（α+β）相对功率比（DTABR）。对2组DTABR值及视觉分析结果进行比较，同时观察SD组患者EEG双侧大脑脑电活动的对称性。 结果： 与正常对照组相比，SD患者慢波活动增多，DTABR值增大，差异均有统计学意义（P<0.01）。SD患者左侧DTABR值高于右侧对应部位，以前颞叶明显不对称为著，差异均有统计学意义（P<0.05）。 结论： 定量EEG能够反映SD患者脑功能的变化，为理解SD的电生理学机制提供客观量化指标。

Abstract:

Objective: To explore the characteristics of quantitative analysis of EEG in patients with semantic dementia (SD). Methods: Nine SD patients and 30 normal controls sex and age matched were selected for electroencephalogram (EEG) examination. The results of the EEG data were visually scored and quantitatively analyzed. The relative power ratio of (δ+θ) / (α+β) (DTABR) at the whole brain, left and right frontal, anterior-temporal, middle-posterior temporal, center, parietal and occipital area was measured respectively. The value of DTABR and the result of visual analysis were compared between the two groups, and the symmetry of EEG activity of bilateral brain in SD patients was observed simultaneously. Results: Compared with the normal control group, the slowwave activity and the DTABR of SD patients were significantly increased (P<0.01). The DTABR on the left brain side was significantly higher than that on the right side in SD patients, especially on the anterior-temporal area (P<0.05). Conclusion: Quantitative EEG can reflect the changes in brain function of SD patients and provide objective quantitative indicators for exploring the electrophysiological mechanism of SD.