阿尔茨海默病患者的视觉环路损害特征及其临床应用的研究进展

Research progress of the characteristics of abnormal visual pathway and its clinical application in patients with Alzheimer's disease

摘要:

阿尔茨海默病（Alzheimer's disease，AD）是老年人中最常见的痴呆类型，表现为进展性、不可逆转的多维度认知功能障碍。视觉功能障碍是AD及其高风险人群轻度认知功能障碍（mild cognitive impairment，MCI）的认知损害特征之一，视觉环路功能障碍是其视觉症状的主要机制。利用神经影像学可以揭示AD谱系患者视觉环路的损害模式，有助于早期识别并干预AD的进展。本文将对AD谱系患者的视觉环路损害特征及其临床应用的研究进展进行综述。

Abstract:

Alzheimer's disease (AD) is the most common form of dementia in the elderly who is characterized by progressive and irreversible loss of multidimensional cognitive function. Visual impairment is one of the features in AD and its high-risk population mild cognitive impairment (MCI) patients, and visual pathway dysfunction is associated with the underlying mechanism. Neuroimaging can reveal subtle changes in visual pathway in AD spectrum patients, which could help to early recognize and intervene in the progress of AD. In this article, we will review the progress of characteristics of abnormal visual pathway and its clinical application in AD spectrum patients.