海马亚区在阿尔茨海默病中的研究进展

Advances in the study of hippocampal subregion in Alzheimer's disease

摘要:

阿尔茨海默病（Alzheimer's disease，AD）是一种进行性的神经系统退行性疾病。海马是AD发病过程中最早且特异性较高的一种标志物，分为CA1~4亚区。海马亚区涉及情景记忆、社会记忆、联想记忆的处理，其改变与衰老、Aβ沉积、tau蛋白过度磷酸化、缺血等影响因素相关。研究海马亚区与AD的相关性，对AD的早期识别及诊断具有重要临床意义，可能为AD的治疗提供新的思路。

Abstract:

Alzheimer's disease (AD) is a progressive neurodegenerative disease. The hippocampus is the earliest and highly specific marker in the pathogenesis of AD, which can be divided into CA1-4 subregions. The hippocampal subregion is involved in the processing of episodic memory, social memory and associative memory, and is associated with aging, Aβ deposition, hyperphosphorylation of tau protein, ischemia and other influencing factors. The study of the changes in the hippocampal subregion in AD is of great clinical significance for the early identification and diagnosis of AD, and may provide new ideas for the treatment of AD.