默认网络子系统介导AD谱系患者情节记忆功能障碍的神经影像学研究进展

Advances in neuroimaging studies about default network subsystem mediating episodic memory dysfunction in AD spectrum patients

摘要:

阿尔茨海默病（Alzheimer's disease，AD）及其风险人群轻度认知障碍（mild cognitive impairment，MCI）是最常见的认知功能障碍，其核心损害表现为情节记忆功能障碍。默认网络（default network，DMN）由核心子系统（Core）、背内侧前额叶子系统（dorsal medial prefrontal cortex，DMPFC）和内侧颞叶子系统（medial temporal lobe，MTL）组成，3个子系统相互协作共同维持情节记忆功能的稳态。然而，AD谱系患者中上述子系统的相互作用模式尚不明确。本文将系统回顾该领域的研究进展，揭示AD谱系患者特有的损害特征，这将为AD谱系疾病早期筛查、进展监控、疗效评估以及相关认知障碍疾病的鉴别诊断提供重要的思路。

Abstract:

Alzheimer's disease (AD) and its risk population of mild cognitive impairment (MCI) are the most common cognitive impairments, whose core impairment is episodic memory dysfunction. The default network (DMN) is composed of the core subsystem (Core), the dorsal medial prefrontal cortex (DMPFC) subsystem and the medial temporal lobe (MTL) subsystem. The three subsystems cooperate with each other to maintain the steady state of episodic memory function. However, the patterns of interaction of these subsystems in AD spectrum patients are not clear yet. In this study, we will systematically review the advances of neuroimaging studies in this field, and the specific impairment characteristics of AD spectrum patients, which will provide important ideas for early screening, progression monitoring, efficacy evaluation and differential diagnosis of AD spectrum diseases.