头颈鳞癌中人乳头瘤病毒的检测及意义

Detection of human papilloma virus and its clinical significance in head and neck squamous cell carcinoma

摘要:

头颈鳞癌是人体最常见的恶性肿瘤之一，近年来头颈鳞癌的发病率呈逐年上升趋势。新近研究发现感染高危型人乳头瘤病毒（human papilloma virus，HPV）与头颈鳞癌的发病具有相关性。HPV相关头颈鳞癌是头颈鳞癌的一个独立亚组，往往表现出淋巴转移早、分期晚，但对放化疗敏感、预后相对较好的临床特性。头颈鳞癌中HPV的检测方法众多且各具特点，但多未在临床广泛应用。本文就HPV的检测方法及临床应用的最新进展作一综述，旨在提高临床医师对头颈鳞癌中HPV检测方法和应用的认识，为推广临床治疗策略提供帮助。

Abstract:

Head and neck squamous cell carcinoma is one of the most common malignant tumors，and its incidence has been increasing year by year. Recently，more and more researches have revealed that the infection of high-risk human papilloma virus（HPV） is closely related with head and neck squamous carcinoma. HPV-related head and neck squamous cell carcinoma is an independent subgroup，with the characteristics of early lymph node metastasis and the advanced tumor stage，but chemoradiotherapy sensitivity and relatively good prognosis. There are several methods for HPV detection in head and neck squamous cell carcinoma，each with its advantages and disadvantages，however，most of them are not widely used in clinical practice. Therefore，this article reviews recent researches upon the detection methods of HPV in head and neck squamous cell carcinoma and the significance in clinical practice，which aims to raise the knowledge of HPV detection，and promote the clinical application in the treatment strategy of head and neck squamous cell carcinoma.