SFRP1-Wnt信号通路在骨肉瘤中的研究进展

Research progress of SFRP1-Wnt signaling pathway in osteosarcoma

摘要:

Wnt信号通路通过调节许多组织的发育和体内平衡，控制胚胎发育和成体稳态，其信号异常不仅会造成发育缺陷，而且与多种癌症的发生密切相关。近年来，研究发现Wnt信号通路在骨肉瘤的发生发展及转移中扮演重要角色。分泌型卷曲相关蛋白1（secreted frizzled-related protein 1，SFRP1）因部分结构与Wnt信号通路的卷曲蛋白受体（frizzled，FZD）高度同源而被认为是一类Wnt通路调节剂，调节骨肉瘤中的Wnt信号通路。本文就SFRP1-Wnt信号轴对骨肉瘤的调节作用进行综述。

Abstract:

The Wnt signaling pathway regulates the development and homeostasis of many tissues，and controls embryonic develop－ment and adult homeostasis. Abnormal signals in the Wnt signaling pathway not only cause developmental defects，but also are closely related to the occurrence of various cancers. In recent years，Wnt signaling pathway has been found to be associated with the formation，migration and apoptosis of osteosarcoma. Secreted frizzled-related protein 1（SFRP1） is considered to be a type of Wnt pathway modu－lator because its partial structure is highly homologous to the frizzled（FZD） protein receptor of Wnt signaling pathway，which regulates the Wnt signaling pathway in osteosarcoma. This article reviews the regulation of SFRP1-Wnt signaling pathway in osteosarcoma.