女童快进展中枢性性早熟与血清抗米勒管激素和抑制素B水平相关性研究

Study on rapidly progressive central precocious puberty association with serum anti-Müllerian hormone and inhibin B levels in girls

摘要:

目的：探讨中枢性性早熟（central precocious puberty，CPP）女童血清抗米勒管激素（anti-Müllerian hormone，AMH）和抑制素B（inhibin B，INHB）与进展快慢的相关性，为快进展CPP（rapidly progressive CPP，RP-CPP）女童的诊疗提供新的方向。方法：选取55例在江西省儿童医院内分泌遗传代谢科专科门诊诊治的CPP女童纳入研究，根据进展指标分别将其中32例纳入RP-CPP组、23例纳入慢进展CPP（slowly progressive CPP，SP-CPP）组。同时纳入30例正常未发育女童作为正常对照组。结果：快进展CPP组、慢进展CPP组与正常对照组之间的血清AMH水平差异有统计学意义（P<0.05）。快进展CPP组和正常对照组及慢进展CPP组和正常对照组之间的INHB水平差异均有统计学意义（P<0.05），快进展CPP组与慢进展CPP组差异无统计学意义（P >0.05）。快进展CPP组AMH水平与黄体生成素（luteinizing hormone，LH）基础值、卵泡刺激素（follicle-stimulating hormone，FSH）基础值、LH峰值、FSH峰值呈显著负相关。结论：AMH和INHB与中枢性性早熟女童的病程进展快慢有关，AMH和INHB是临床工作中快速识别女童RP-CPP的2项潜在实验室指标。

Abstract:

Objective：To study the correlation and clinical significance of the serum anti-Müllerian hormone（AMH） and inhibin B（INHB） levels of girls with the progression of central precocious puberty（CPP），and point out new directions for the diagnosis and treatment of rapidly progressive CPP（RP-CPP） girls. Methods：A total of 55 girls with CPP who were diagnosed in Department of Endocrinology，Genetics and Metabolism of Jiangxi Provincial Children’s Hospital were included in our research. Then，32 of them were divided into RP-CPP group（n=32） and 23 of them into SP-CPP group（n=23） according to the progressive index. Meanwhile，30 immature and age-matched girls were collected as the normal control group. Results：The serum levels of AMH in RP-CPP，SP-CPP and control groups were significantly different（P<0.05）. Significant differences were founded between RP-CPP group and control group and also between SP-CPP and control group（P<0.05），while no statistical differences were found between RP-CPP group and SP-CPP group（P >0.05）. AMH levels of girls were significantly negatively correlated with basal-LH，basal-FSH，peak-LH，and peak-FSH in the RP-CPP group. Conclusion：Our results suggest that AMH and INHB are associated with the progress of RP-CPP girls，meanwhile they are potential laboratory indicators to identify RP-CPP girls rapidly in clinical work.