血中鸢尾素水平与肥胖和2型糖尿病的关系

Relationship between irisin level in blood with obesity and type 2 diabetes mellitus

摘要:

目的：探讨血中鸢尾素水平与肥胖和2型糖尿病（type 2 diabetes mellitus，T2DM）相关指标的关系。方法：选取79例T2DM患者和非糖尿病对照80例，根据体质指数（body mass index，BMI）进一步分为正常组、肥胖组、T2DM组、T2DM肥胖组。应用全自动生化分析仪、全自动血糖检测仪、全自动糖化血红蛋白检测仪检测各组肥胖和T2DM相关指标，用酶联免疫吸附法检测血中鸢尾素、白细胞介素-1β（interleukin-1β，IL-1β）水平。采用方差分析和线性回归分析的方法分析数据。结果：T2DM肥胖组鸢尾素水平明显高于正常组，肥胖组和T2DM肥胖组鸢尾素水平明显高于T2DM组，糖尿病组IL-1β水平明显高于正常组，T2DM肥胖组IL-1β水平明显高于肥胖组。鸢尾素与体质量、BMI呈正相关。受试者工作特征（receiver operating character－istic，ROC）曲线结果显示鸢尾素在非糖尿病组、糖尿病组中的曲线下面积分别是0.653、0.854。结论：鸢尾素水平可能与肥胖存在一定的相关性，与T2DM不相关。鸢尾素在非糖尿病人群和糖尿病人群中对肥胖都有一定的辅助诊断价值。

Abstract:

Objective：To discuss the relationship between irisin level in blood and obesity and type 2 diabetes mellitus（T2DM） related parameters. Methods：We recruited 79 T2DM patients and 80 non-diabetic controls. According to body mass index（BMI），these sub－jects were further divided into normal group，obese group，T2DM group，and T2DM obese group. Obesity and T2DM related parameters were measured by automated biochemical analyzer，automated glucose analyzer and automated glyco-hemoglobin analyzer，and the level of irisin and interleukin-1β（IL-1β） was tested by enzyme-linked immunosorbent assay（ELISA）. Analysis of variance（ANOVA） and linear regression analysis were used to analyze the data. Results：The irisin level in T2DM obese group was significantly higher than that in normal group. The irisin level in both obese and T2DM obese group was significantly higher than that in T2DM group. The IL-1β levels in diabetic groups were significantly higher than the level in normal group，and the level of IL-1β in T2DM obese group was significantly higher than that in obese group. Irisin was positively correlated to weight and BMI. The receiver operating character－istic（ROC） curve analysis showed that the area under the curve of irisin in non-diabetic groups and diabetic groups was 0.653 and 0.854 respectively. Conclusion：The irisin level may be related to obesity to a certain extent，but not related to T2DM，which has a certain diagnostic value for obesity in non-diabetic and diabetic populations.