长链非编码RNA调控脑缺血/再灌注损伤作用机制的研究进展

Advances in effects of long noncoding RNA on regulating ischemia-reperfusion injury

摘要:

缺血性脑卒中（ischemia stroke，IS）具有高发病率和高致死率特征。现有治疗IS的方法临床效果有限，仍需探寻治疗IS的新方法。越来越多的研究证实长链非编码RNA（long noncoding RNA，LncRNA）对脑缺血/再灌注损伤有保护作用，被期望成为治疗IS的潜在靶点。本文就LncRNA对脑缺血/再灌注损伤的保护作用及其机制研究进展作一综述，以期为LncRNA对IS作用的临床研究提供思路；提出在进一步做临床研究前，需要研究LncRNA是否有诱发IS颅内出血转化的安全性问题，并设计研究适合人用的剂型和给药方式。

Abstract:

Ischemia stroke（IS） has high morbidity and high mortality worldwide. As effective treatments for IS remain limited，a better new therapeutic intervention target is needed. Increasing evidence suggests that long noncoding RNA（LncRNA） has protective effect on cerebral ischemia-reperfusion injury，and it is expected to be a potential target for the treatment of IS. This paper has reviewed the protective effects and the mechanism of LncRNA on IS，so as to provide ideas for further clinical research on the related fields. Additionally，this paper has pointed out that it would be necessary to study whether LncRNA could induce intracranial hemorrhage transformation in IS before further applying it to clinical research，and it would be suggested to design dosage forms and administration methods suitable for human use.