神经干细胞重编程及其应用的研究进展

Progress of neural stem cell reprogramming and its application

摘要:

神经干细胞重编程技术可将体细胞生成具有疾病相关表型的成熟人类神经元，为神经障碍疾病的细胞治疗带来前景。笔者就神经干细胞重编程的调控因素、提高重编程效率以及应用于神经障碍疾病建模等方面的研究进展进行综述。

Abstract:

Neural stem cells（NSCs） reprogramming technology can generate mature human neurons with disease-related phenotypes from somatic cells，bringing a prospect for cell therapy of neurological disorders. In this paper，the regulatory factors of NSCs reprogramming，the improvement of reprogramming efficiency and the application in the modeling of neurological disorders are reviewed.