SOCS-3在肝脏疾病中的作用研究进展

Research progress on the role of SOCS-3 in liver diseases

摘要:

细胞因子信号转导抑制蛋白-3（suppressor of cytokine signaling，SOCS-3）是一种细胞因子信号转导阻抑蛋白，参与体内多种信号转导通路的调节。研究发现，SOCS-3与肝纤维化、病毒性肝炎和肝肿瘤的发生发展均存在一定的关系，并且干扰素的抗病毒疗效与SOCS-3的遗传学表达改变密切相关。本综述将对SOCS-3的结构、分子功能及近年来在肝疾病中的相关研究进行简要总结。

Abstract:

Suppressor of cytokine signaling-3（SOCS-3） is a kind of cytokine signaling transduction inhibitory protein，involving in the regulation of multiple signal transduction pathways in vivo. It’s found that SOCS-3 plays an important role in the occurrence and development of liver fibrosis，viral hepatitis and liver tumors，and the antiviral efficacy of interferon is closely related to the genetic expression of SOCS-3. This review briefly summarizes the structure and molecular function of SOCS-3 and related research in liver diseases in recent years.