铁死亡的调控机制及在肝脏疾病中的研究进展

Regulatory mechanism of ferroptosis and its advances in liver diseases

摘要:

铁死亡是铁依赖性的活性氧过度累积导致氧化还原失衡的一种细胞死亡方式，与铁代谢和脂质过氧化代谢等途径相关的基因均参与其调控，且调控机制较复杂。近年研究显示，铁死亡在肝脏疾病中发挥重要调控作用。本文对铁死亡的调控机制及在肝脏疾病中的研究进展进行综述，以期为此类疾病的临床治疗提供一个新的方向。

Abstract:

Ferroptosis is a cell death mode caused by the excessive accumulation of iron dependent reactive oxygen species，which leads to the imbalance of redox. Genes related to iron metabolism and lipid peroxidation metabolism are involved in its regulation，and the regulatory mechanism is relatively complicated. Recent studies have reported the important roles of ferroptosis in liver diseases. This paper reviews the regulatory mechanism of ferroptosis and its research progress in liver diseases，with a view to providing a new direction for clinical treatment of such diseases.