低剂量阿司匹林在产科及辅助生殖中的研究进展

Research progress of low-dose aspirin in obstetrics and assisted reproduction

摘要:

阿司匹林是一种具有抗炎和抗血小板特性的环氧化酶抑制剂。近年来低剂量阿司匹林（low-dose aspirin，LDA）在产科及辅助生殖中的应用范围不断拓展，尤其是用于预防子痫前期已被多个国家指南推荐。LDA主要通过抑制环氧酶活性发挥抗血小板聚集作用，可有效改善胎盘浅着床引起的胎盘灌注不良，在胎儿生长受限、早产、产科抗磷脂综合征、辅助生殖等领域的适用指征也逐渐拓宽。本文就LDA在产科及辅助生殖应用的指南推荐意见和研究进展进行综述。

Abstract:

Aspirin is a cyclooxygenase inhibitor with anti-inflammatory and anti-platelet properties. As indicated by several national guidelines, low-dose aspirin (LDA) use in obstetrics and assisted reproduction has recently increased, particularly for the prevention of preeclampsia. At the same time, LDA can effectively improve the placental hypoperfusion by inhibiting the activity of cyclooxyge-nase to exert the effect of anti-platelet aggregation, and its indications for fetal growth restriction, preterm birth, obstetric antiphospholipid syndrome, assisted reproductive technology, and other conditions have been gradually expanded. This article reviews the recommendations and research progress of various guidelines on the application of low-dose aspirin in obstetrics and assisted reproduction.