白细胞衍生趋化因子2在肝脏疾病中的作用及研究进展

Role and research progress of leukocyte cell-derived chemotaxin-2 in liver diseases

摘要:

肝脏是人体重要的新陈代谢和解毒器官，当受到各种致病因素侵袭时，肝脏正常的生理生化功能受到影响，从而导致肝脏疾病。白细胞衍生趋化因子2（leukocyte cell-derived chemotaxin-2，LECT2）是一种主要由肝细胞分泌的碱性蛋白，在人体的各个系统中有着诸多重要功能，如控制和调节免疫系统、改变葡萄糖代谢、促进骨骼生长、控制细胞周期和分裂等。不同疾病状态下LECT2水平变化的临床意义是不同的。在不同类型的肝病患者中，血清和肝组织中LECT2水平与肝功能下降、病理分期密切相关。大量的动物研究和体外实验表明，LECT2的异常表达导致代谢紊乱、肝脏炎症、纤维化及肿瘤的发生。本文通过复习近几年国内外的相关文献，对LECT2的分子概念及其与肝脏疾病的发生发展、侵袭转移等之间的关系进行综述，以探讨LECT2是否可作为治疗不同肝病的潜在靶点。

Abstract:

The liver is an important metabolism and detoxification organ of the human body. When affected by various pathogenic factors, the normal physiological and biochemical functions of the liver are affected, leading to liver diseases. Leukocyte cell-derived chemotaxin-2 (LECT2) is a basic protein secreted mainly by liver cells, which has many important functions in various systems of the human body, such as controlling and regulating the immune system, changing glucose metabolism, promoting bone growth, controlling cell cycle and division, etc. The clinical significance of changes in LECT2 levels in different disease states is different. In patients with different types of liver diseases, the level of LECT2 in serum and liver tissue is closely related to the decline of liver function and pathological staging. A large number of animal studies and in vitro experiments have shown that the abnormal expression of LECT2 leads to metabolic disorders, liver inflammation, fibrosis and tumors. This article reviews the relevant domestic and foreign literature in recent years, and reviews the molecular concept of LECT2 and its relationship with the occurrence and development of liver diseases, invasion and metastasis, etc., to explore whether LECT2 can be used as a potential target for the treatment of different liver diseases.